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 The presence of acetaminophen in hydrocodone -containing items prevents many medication clients from taking unreasonable sums.  Nonetheless, a few clients will get around this by removing a part of the acetaminophen utilizing hot/cold water, exploiting the water-dissolvable component of the medication.  It isn't phenomenal for addicts to have liver issues from burning-through exorbitant measures of acetaminophen throughout an extensive stretch of time; taking 10,000 to 15,000 milligrams (10 to 15 grams) of acetaminophen in a time of 24 hours regularly brings about serious hepatotoxicity, and dosages in the scope of 15,000–20,000 milligrams daily have been accounted for as fatal.[1] It is this factor that leads numerous addicts to utilize just single element narcotics like OxyContin.  Day by day utilization of hydrocodone ought not surpass 40 milligrams in patients not lenient to narcotics. Nonetheless, the 2006 PDR (Physicians Desk Reference) unmistakably expresses that Norco 10,